Scuffling filmmaker Dan Burton (Jason Segel) and his ambitious actress wife Lisa (Samara Weaving) agreed that a weekend at their isolated lakeside cabin might be the cure they needed for their foundering relationship. Or, that was the story, since each had planned to murder the other. Add a trio of degenerate fugitives (Timothy Olyphant, Juliette Lewis, Keith Jardine) and the stage is set for darkly comic mayhem.